creatine kinase, brain | |
---|---|
Crystallographic structure of chicken brain creatine kinase.[1] | |
Identifiers | |
Symbol | CKB |
Alt. symbols | CKBB, CK-1 |
Entrez | 1152 |
HUGO | 1991 |
OMIM | 123280 |
PDB | 1QH4 |
RefSeq | NM_001823 |
UniProt | P12277 |
Other data | |
EC number | 2.7.3.2 |
Locus | Chr. 14 q32.3 |
creatine kinase, ectopic expression | |
---|---|
Identifiers | |
Symbol | CKBE |
Entrez | 1156 |
HUGO | 1992 |
OMIM | 123270 |
Other data | |
Locus | Chr. 14 q32.3 |
Brain-type creatine kinase also known as CK-BB is a creatine kinase which in humans is encoded by the CKB gene.[2]
Contents[hide] |
The protein encoded by this gene, CK-BB, consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CK-BB forms tightly coupled microcompartments for in situ regeneration of ATP that has been used up. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in brain, smooth muscle as well as in other tissues and cells such as neuronal cells, retina, kidney, bone etc. In heart, a heterodimer (CK-MB) consisting of one CK-B brain-type CK subunit and one CK-M muscle-type CK subunit is prominently expressed The encoded CK-BB and CK-MB proteins are members of the ATP:guanido phosphotransferase protein family.[3]
Ectopic expression (CKBE) of the B (brain) type of creatine kinase (CK-BB) in red cells and platelets is a rare, benign anomaly detected during a newborn screening program for Duchenne muscular dystrophy.[4][5]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.